In a post on his Facebook page, artist Joe Madureira hints that the Darksiders franchise will live on past Darksiders 2.
Darksiders-- DS is not dead!!! The new owner, Nordic seems very committed to continuing the series. As far as my involvement, I can't say at this point. Hopefully we will all have exciting news about the franchise soon!!!!!!

That is in no way a confirmation of anything but it is the first positive news we've heard about the series continuing. Hopefully Nordic Games is indeed committed to continuing the series as Madureira has indicated.