You'll be able to save even more space if you don't care about the campaign.
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Call of Duty: Vanguard will be released on November 5, 2021, which is just four short days away now. We knew that the install size for Vanguard would be "up to 50% smaller" than prior releases, but it wasn't until today that we get a much clearer picture as to what that actually means.

Activision pushed out a new blog post that details the PC system requirements for Call of Duty: Vanguard. For the absolute bare minimum, you're going to need 36GB at launch for the game, which honestly isn't too bad. Of course, this size is just for the multiplayer and Zombies components only and does not include an install of the single-player campaign.

From there, the size jumps up to 61GB at launch for the campaign, multiplayer, and Zombies. If you want to get the optional "Hi-Rez assets" you will need another 32GB to 64GB of storage space on top of the 61GB.

Activision breaks down the system requirements into four tiers: Minimum, recommended, competitive, and Ultra RTX. Unfortunately, the company stopped just short of saying what framerates and resolutions they were targeting for all four tiers, with the exception of the "Ultra RTX" tier.

MINIMUM
The minimum specs needed to play Call of Duty: Vanguard
RECOMMENDED
The recommended specs to run at 60FPS in most situations with all options set to high
COMPETITIVE
The competitive specs to run at a high FPS for use with a high refresh monitor
ULTRA RTX
The ultra specs to run the game at a high FPS in 4K resolution
OS Windows 10 64 Bit (latest update) Windows 10 64 Bit (latest update) or Windows 11 64 Bit (latest update) Windows 10 64 Bit (latest update) or Windows 11 64 Bit (latest update) Windows 10 64 Bit (latest update) or Windows 11 64 Bit (latest update)
CPU Intel Core i3-4340 or AMD FX-6300 Intel Core i5-2500K or AMD Ryzen 5 1600X Intel Core i7-8700K or AMD Ryzen 7 1800X Intel Core i9-9900K or AMD Ryzen 9 3900X
RAM 8GB RAM 12GB RAM 16GB RAM 16GB RAM
STORAGE SPACE 36GB at launch (Multiplayer and Zombies only) 61GB at launch 61GB at launch 61GB at launch
HI-REZ ASSETS CACHE Up to 32GB Up to 32GB Up to 32GB Up to 64GB
VIDEO CARD NVIDIA GeForce GTX 960 or AMD Radeon RX 470 NVIDIA GeForce GTX 1060 or AMD Radeon RX 580 NVIDIA GeForce RTX 2070/RTX 3060 Ti or AMD Radeon RX 5700 XT NVIDIA GeForce RTX 2070/RTX 3080 or AMD Radeon RX 6800 XT
VIDEO MEMORY 2GB 4GB 8GB 10GB
GRAPHIC DRIVER NVIDIA: 472.12
AMD: 21.9.1
NOTES All Specifications require a broadband connections and DirectX 12 compatibility.
Additional storage space may be required for mandatory game updates.
Hi-Rez assets cache is optional disk space that can be used to stream high resolution assets. That option can be turned off in the game settings.
Only Intel/AMD processors (with AVX Instruction Set) are supported at this time.

If you are already planning on picking up the game, or have pre-purchased it already, you will be happy to hear that pre-loading begins on November 2 at 10AM (PT) for PC. A new trailer for Vanguard, which focuses on the PC release, was also released today. You can (hopefully) find it embedded below so long as YouTube doesn't block it for whatever reason.