Game director had put a lot of thought into the idea.
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During a recent Bethesda stream, DOOM Eternal game director Hugo Martin said that he put a lot of thought into how to incorporate a female Slayer into the franchise. He says that he would want the female Slayer to be more than just a simple reskin of the Slayer we have all come to know (and love?).

You can listen to Martin field the question at the 59m32s mark of their recent Twitch stream, or read the transcript below.

"I've thought about it, actually. I think if we did it, I'd want it to be lethal," Martin said. "I think it's interesting how it would impact the glory kills, the kind of weapons that she would have, the fighting style—certainly all aggression, absolutely, but a different type of aggression.

"I would really strive to allow it to impact the gameplay in a way that was meaningful. I've definitely put a lot of thought into that.

"When it comes to designing the action, you think about, like, if the Slayer is a Ferrari, then what would a female Slayer be? What would a medieval Slayer be? How would that affect things? What sort of analogies could you draw from that, allow that to influence the experience? So I don't know. It definitely would be cool."
As VGC points out, the Doom SLayer fights alongside a female marine named Crash. According to her bio in Quake 3, she was the Slayer's military instructor. So the idea of a female Slayer really isn't too far off the mark here.

DOOM Eternal was released in March 2020 for the PlayStation 4, Xbox One, and PC. The second expansion for the game, The Ancient Gods: Part Two, will be released soon.